Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis.
Arthritis Rheum. 1992 May;35(5):550-6.
OBJECTIVE: To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.
METHODS: Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high-performance liquid chromatography with coulometric detection.
RESULTS: CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.
CONCLUSION: Alow rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.