Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis.

By Russell IJ, Vaeroy H, Javors M, Nyberg F.

Arthritis Rheum. 1992 May;35(5):550-6.

OBJECTIVE: To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.

METHODS: Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high-performance liquid chromatography with coulometric detection.

RESULTS: CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.

CONCLUSION: Alow rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.

2018-06-11T14:24:08-07:00Monday, February 22, 2016|Science & Research|